|
rs1057519328
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs146597836
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs746055479
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs750868279
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs751454741
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs752615209
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs755659290
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs774164456
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs886039866
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs886040969
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Of these 5 loci, 2 were found to be significantly associated with BD susceptibility: rs17375018 (G vs. A, OR = 1.50, 95% CI: 1.34-1.68, <i>P</i> < .00001) and rs924080 (T vs. C, OR = 1.36, 95% CI: 1.29-1.43, <i>P</i> < .00001).
|
31814470 |
2019 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
SNPs (rs924080 and rs11209032) of the IL23R-IL12RB2 region were found to be associated with BD in a Northern Chinese Han population.
|
27660093 |
2016 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Six SNPs in IL23R-IL12RB2 were found to be associated with BD after Bonferroni correction for multiple testing, the most significant of which were rs17375018 (OR for G allele 1.51, 95% CI 1.27-1.78, P(unadj) = 1.93 × 10(-6) ), rs7517847 (OR for T allele 1.48, 95% CI 1.26-1.74, P(unadj) = 1.23 × 10(-6) ), and rs924080 (OR for T allele 1.29, 95% CI 1.20-1.39, P = 1.78 × 10(-5) ).
|
22378604 |
2012 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Similarly, rs1518111, which showed strong linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes.
|
25941808 |
2015 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95% CI] 1.02-1.40, unadjusted P [P(unadj) ] = 2.53 × 10(-2) ; adjusted P [P(adj) ] = 1.43 × 10(-2) ), and rs1554286 demonstrated a trend toward association (P(unadj) = 6.14 × 10(-2) ; P(adj) = 3.21 × 10(-2) ).
|
22378604 |
2012 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
|
20622878 |
2010 |
|
rs1800871
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
rs1800871
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs1800871
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Similarly, rs1518111, which showed strong</span> linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1800871
|
|
T |
0.830 |
GeneticVariation |
GWASDB |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |